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Using of Third and Fourth Order Derivative Spectra to Simultaneous Determination of Olanzapine and Ephedrine in Its Pure and Pharmaceutical Formulations | ||
| Ibn Al-Haitham Journal For Pure And Applied Science | ||
| Article 1, Volume 30, Issue 1, 2017, Pages 366-375 | ||
| Authors | ||
| Mumin F. Hamad Al-Samarrai; Imad T. Hanoon; Diana A. Shakir; Khalaf F. Al-Samarrai; Sarmad B. Dikran | ||
| Abstract | ||
| Two new simultaneous spectrophotometric methods for determination of Olanzapine and Ephedrine depend on third (D3) and fourth (D4) derivative of zero spectrum of two drugs were developed. The peak – to- base line, peak to peak and area under peak were found proportional with concentration of the drugs up to (4-24 µg/ml-1) at known experimental wavelengths. The results showed that the method was precise and accurate through RSD% (0.5026-4.0273),( 0.2399 -6.9888) and R.E% (-2.3889-0.8333) , )-2.9444-0.2273) while the LOD (0.0057- 0.8510 μg.ml-1), ( 0.0953-0.9844 μg.ml-1) and LOQ (0.0173- 2.5788μg.ml-1),( 0.5774-2.9829 μg.ml-1) were found for the two drugs respectively. The methods were applied ide to the determination of Olanzapine and Ephedrine in pharmaceutical preparations successfully. | ||
| Keywords | ||
| ephedrine; Olanzapine; derivative spectrum | ||
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