- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
The neurobehavioral and withdrawal effects of diazepam in adult male rats | ||
| Kufa Journal For Veterinary Medical Sciences | ||
| Article 1, Volume 5, Issue 2, 2014, Pages 306-318 | ||
| Authors | ||
| Mohammed Jawad kadhim; Falah Muosa Kadhim AL-Rekabi; Duriad Abdulhadi Abass | ||
| Abstract | ||
| The study conducted to evaluate the neurobehavioral effects and dependence in adult male rats which showed significant decrease (p<0.05) in exploration, vestibular system (increasing time of rotating on negative geotaxis apparatus), decrease cognition, short term memory, locomotors activity (decrease time of rotating on Rota rod apparatus), where these results was confirmed by histopathological changes of brain which represent by congestion, perivascular edema, focal gliosis and mononuclear cells infiltrations in groups treated with diazepam. The results of withdrawal study after one week of stop dosing of diazepam treatment showed signs of addiction represented by hyperactivity, restlessness, diarrhea and goose flesh in dose dependent manner. | ||
| Keywords | ||
| Neurobehavioral; withdrawal; Diazepam; male rat | ||
|
Statistics Article View: 87 PDF Download: 51 |
||