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Oxidative Stress and Pathogenesis of Polycystic Ovary Syndrome | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 28, Issue 1, 2015, Pages 45-48 | ||
| Author | ||
| Sawsan Mohammad | ||
| Abstract | ||
| Background: Polycystic ovary syndrome (PCOS) is considered to be the most common endocrine disorder in reproductive age. It is also one of the most enigmatic diseases. The etiology of PCOS is complex and is uncertain; recently, it has been shown that it is associated with excessive oxidative stress. Objective: Is to find whether PCOS is associated with oxidative stress by measuring one of the oxidative stress markers “malondialdehyde” (MDA). Methods: Between October 20012 and October 2013, fifty PCOS patients and fifty healthy controls were recruited into the study where the following parameters were determined for PCOS patients and compared to healthy control: Serum Follicle stimulating hormone (FSH) and Luteinizing hormone (LH) level along with LH/FSH ratio and testosterone levels. The concentration of MDA as marker of oxidative stress was determined according to Buege & Aust enzymology. Results: The study showed that the body mass index and LH, FSH, LH/FSH ratio, and testosterone were significantly different between the two groups (34.20±2.12 vs. 29.23±2.3; P=0.041, 8.83±2.34 vs. 8.20±1.76; P=0.012, 4.69±1.62 vs. 5.03±1.36; P=0.008, 2.05±0.56 vs.1.73±0.39; P=0.001, 2.09±1.27 vs. 0.98±1.24; P=0.005 respectively). The serum MDA level is product of lipid peroxidation as the oxidative stress marker where significantly higher in PCOS patients than in healthy controls (0.83±0.56 vs.0.433±0.234; P=0.001). Conclusion: The oxidative stress is increased in PCOS patients indicated by measurement of serum MDA level which is one of the oxidative stress markers and this may contribute to the pathogenesis of PCOS. | ||
| Keywords | ||
| oxidative stress; polycystic ovary syndrome | ||
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