Naser Mohammed, A., AliAbduladheemYaseenAbbood, , Abdul RazakAbdul Wahab, H., Mahdi Rahma, A. (2015). Estimation of Urinary Vitamin D Binding Protein as a Biomarker in Type 2 Diabetic Nephropathy and its correlation with estimated Glomerular Filtration Rate. , 28(3), 145-150.
Ali Naser Mohammed; AliAbduladheemYaseenAbbood; Hazim Abdul RazakAbdul Wahab; Abbas Mahdi Rahma. "Estimation of Urinary Vitamin D Binding Protein as a Biomarker in Type 2 Diabetic Nephropathy and its correlation with estimated Glomerular Filtration Rate". , 28, 3, 2015, 145-150.
Naser Mohammed, A., AliAbduladheemYaseenAbbood, , Abdul RazakAbdul Wahab, H., Mahdi Rahma, A. (2015). 'Estimation of Urinary Vitamin D Binding Protein as a Biomarker in Type 2 Diabetic Nephropathy and its correlation with estimated Glomerular Filtration Rate', , 28(3), pp. 145-150.
Naser Mohammed, A., AliAbduladheemYaseenAbbood, , Abdul RazakAbdul Wahab, H., Mahdi Rahma, A. Estimation of Urinary Vitamin D Binding Protein as a Biomarker in Type 2 Diabetic Nephropathy and its correlation with estimated Glomerular Filtration Rate. , 2015; 28(3): 145-150.

Estimation of Urinary Vitamin D Binding Protein as a Biomarker in Type 2 Diabetic Nephropathy and its correlation with estimated Glomerular Filtration Rate

IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 28, Issue 3, 2015, Pages 145-150
Authors
Ali Naser Mohammed; ; Hazim Abdul RazakAbdul Wahab; Abbas Mahdi Rahma
Abstract
Background: Diabetic nephropathy is one of the most common complications, which may lead to chronic kidney disease in diabetic patients.
Objective:The studyobjectiveis to assess the role of urinary vitamin D binding protein as biomarker before onset of nephropathy in type 2 diabetes.
Patients and Methods:The urinary vitamin D binding protein levels were measured by ELIZA , estimated glomerular filtration rate levels were measured by the Chronic Kidney Disease-Epidemiology (CKD-EPI) equation. Ninety individuals were involved in this study which comprises 20 individuals apparently healthy (group I), 40 diabetic patients with normal eGFR (≥ 90 mil/min/1.73m2) and 30 diabetic patients with abnormal value of eGFR (˂ 90 mil/min/1.73m2) (group III).
Results:The mean urinary vitamin D binding protein in all groups showed a gradual increase with a significance P values. A negative correlation was obtained between vitamin D binding proteinand estimated glomerular filtration rate in group I with non significant P-value and group IIIwith significant P-value.
Conclusion:Since the increased vitamin D binding protein levels were negatively correlated with decreased estimated glomerular filtration rate levels, so vitamin D binding protein level can be considered as a novel predictor for monitoring type 2 diabetes before onset of diabetic nephropathy.
Keywords
vitamin D binding protein; estimated glomerular filtration rate; diabetic nephropathy
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