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Association between Insulin Resistance and Insulin like Growth Factor-1 in Gestational Diabetic Women | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 28, Issue 4, 2015, Pages 168-172 | ||
| Author | ||
| Noor Thair Tahir | ||
| Abstract | ||
| Background: Insulin resistance has been identified as a pathogenic of diabetes mellitus, serum insulin-like growth factor-1, and may have a role in the maintenance of glucose homeostasis. Objective: The aim of the present work is to study the relation between insulin resistance and insulin-like growth factor-1 in diabetic women with gestational age of (24-28) weeks and after 3 months of delivery. Patients and Methods: A total of 88 women with gestational age of (24-28) weeks and after 3 months of delivery were enrolled in the study. Fourty four (44) women with diabetes mellitus and a case control study consists of 44 women without diabetes mellitus were recruited from AL-Yarmuk Teaching Hospital and the National Diabetic Center/ Al- Mustansiriya University during the period from May 2014 to July 2015; their age range was (20-40) years. Fasting blood samples were collected from all the subjects to measure serum glucose, glycated hemoglobin, serum insulin, lipid profile, and insulin like growth factor-1. Results: The results showed that the means value of fasting serum insulin, homeostasis model assessment-2 for insulin resistance, and insulin like growth factor-1 were significantly increased in diabetic women with gestational age of (24-28) weeks when compared to the control group and in diabetic women after 3 months of delivery when compared to their levels in the control group, (P<0.05). There was a significant positive correlation between serum insulin like growth factor-1 levels verse homeostasis model of assessment-2 for insulin resistance in diabetic women with gestational age of (24-28) weeks and after 3 months of delivery. A significant positive correlation was found between insulin like growth factor-1 levels verse homeostasis model assessment-2 for sensitivity and beta cell dysfunction in diabetic women with gestational age of (24-28) weeks. Conclusions: Higher maternal insulin like growth factor-1 levels at mid gestation may indicate greater placental and fetal growth, and insulin resistance. | ||
| Keywords | ||
| Gestational diabetes mellitus; insulin resistance; homeostasis model assessment; insulin like growth factor; HOMA | ||
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