Effect of anti-TNF- tumor necrosis factor therapy on lipid profile in a sample of patients attending Baghdad teaching hospital

Abdull Latif, Nazar; Hussein, Ali; AH Mousa, Atta

	Effect of anti-TNF- tumor necrosis factor therapy on lipid profile in a sample of patients attending Baghdad teaching hospital
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 29, Issue 2, 2016, Pages 16-20
Authors
Nazar Abdull Latif; Ali Hussein; Atta AH Mousa
Abstract
Background: Anti-tumor necrosis factor drugs (biological agents) are a class of drugs that are used worldwide to treat inflammatory conditions “these drugs are able to reduce inflammation and stop disease progression”. Objectives: To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic, rheumatoid arthritis and ankylosing spondylitis Patients &methods: A prospective study included 90 patients presenting with 30 Psoriatic arthritis (n=30), ankylosing spondylitis (n=30) rheumatoid arthritis (n=30) who were treated with anti-TNF therapy (infliximab, rituxmab etanercept) and assessed during follow-up period after 6month of therapy. Results: Regarding lipid profile, significance differences (P<0.000) were seen after biological therapy with infliximab infusion in patients with psoriatic arthritis. The current study had significant differences regarding TG and HDL after 6 month of treatment of rheumatoid arthritis patients with rituximab., Significance differences were seen regarding TG and LDL in ankylosing spondylitis patients treated with etanercept Conclusion: Significance differences were seen regarding lipid profile and antitumor necrosis factor alpha therapy regarding psoriatic, Rheumatoid arthritis and ankylosing spondylitis
Keywords
Dyslipidemia; Psoriatic arthritis; Rheumatoid arthritis; AntiTNF

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