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Synthesis and Biological Active of Some Substituted 1,2,4-Triazoles and Their Fused Ring Derivatives | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 13, Issue 3, 2017, Pages 72-87 | ||
| Authors | ||
| Khalid Mahmod Daoud; Mohanad Yakdhan Saleh; Shaima Samer Ismael | ||
| Abstract | ||
| In this paper demonstrated the synthesis of some fused 1,2,4-triazoles derivatives ; Terphthalic acid condensated with ethanol to obtain diethyl terephthalate (1) in the presence of sulfuric acid as catalyst., the ethyl ester (1) was mixed with hydrazine hydrate is ethyl alcohol to give terephthalohydrazide (2). The hydrazide derivative (2) then reacted with ammonium thiocyanate to give yield 2,2'-terephthaloylbis(hydrazinecarbothioamide) (3). 3,4- diamine-bis – 1,2,4-triazole derivative (4) was obtained by reaction of a compound (3) with hydrazine hydrate. 5,5'-(1,4-phenylene)bis(4H-1,2,4-triazole-3,4-diamine) (4) was reacted with a proper aldehyde to yield Schiff bases derivatives (5,6,7).1-(1H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-5-yl)-4-(3H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl) benzene derivatives (8,9,10) were yielded by reaction a Schiff bases derivative with glacial acetic acid. The structures of the synthesized compounds were confirmed by physical and spectral methods. | ||
| Keywords | ||
| heterocyclic compounds; trazole; fused ring; Terephthalic acid | ||
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