- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Synthesis and Antibacterial Evaluation of 2-(chloro / ethyl thio / seleno)-1,8-naphthyridine-3-azetidine Derivatives | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 13, Issue 3, 2017, Pages 104-115 | ||
| Author | ||
| Mohanad Y.Saleh | ||
| Abstract | ||
| Synthesis of new heterocyclic fuse compounds by reaction of N-acetyl-2-amino pyridine with through Vilsmeier-Haack cyclization to give 2-chloro-3-formyl-1,8-naphthyridine (1) , chloro atom changing with selenium (2) or Et-S- group (3) , the formyl group in the compounds (1,2,3) converted to schiff base by react with aryl amine (4-9), shiff base derivatives reaction with chloroacetylchloride in triethylamine to give azetidine ring (10-15) . The structures of synthesized compounds were confirmed by spectral and physical data. Some of the newly synthesized compounds exhibited antibacterial activity. | ||
| Keywords | ||
| schiff base; naphthyridine; azetidine; organoselenium compounds; Vilsmeier; Haack | ||
|
Statistics Article View: 53 PDF Download: 9 |
||