Serological Study for Prevalence Of Igg And Igm Toxoplasmosis Among Cancer Patients

Y.K AL-Bayati, Nagham; Falh Nazzal, Maha; Abd AL-Gabbar Mohammad, Shahad

	Serological Study for Prevalence Of Igg And Igm Toxoplasmosis Among Cancer Patients
Diyala Journal For Pure Science
Article 1, Volume 13, Issue 3, 2017, Pages 91-103
Authors
Nagham Y.K AL-Bayati; Maha falh Nazzal; Shahad Abd AL-Gabbar Mohammad
Abstract
The present study aims to determine the epidemiology of infection parasite Toxoplasma gondii in immunocompetent patients (cancer patients) attending to Medicine City Hospital / Unit tumors with a group of people with a normal immune system as a control . Enzyme Linked Immunosorbent Assay test were used for the purpose of investigate immune antibodies anti-Toxoplasma gondii type IgG and IgM test and Ca19-9 test was used for tumor antibody detection in serum and its relationship with many of the factors that affect the infection . This study was conducted on 296 people , including 178 people with cancer and 59 people normal people (healthy) as control group and 59 of the people infected with toxoplasmosis . Blood samples were collected for the period from the first of October 2015 to the fifteenth of February2016 . The percentage of chronic infection was 52.24% for cancer patients and 100% of patients with Toxoplasma and 30.5% for the control group, while for acute infection, the percentage was 51.37% for cancer patients and 33.89% For patients with Toxoplasma and there was not any infection in Control group and there were no significant differences at the level of probability of p< 0.001.The study results showed that the concentration of immuno glubuline IgG in patients with toxoplasmosis 87.32±35.76 Ul/L , cancer patients and control group were 105. 80 ± 96.11 Ul/L and 63.26±14.20 Ul/L , respectively , while the concentration of serum levels of Ca19-9 for patients with toxoplasmosis , cancer and control group were 145.51 ± 41.13 Ul/L , 197.11± 12.11 Ul/L and 55.49±11.13 Ul/L , respectively. Results of the study showed that there were significant differences infection T. gondii between different types cancer p< 0.001 for acute infection also it was found that there were significant differences for chronic infection p< 0.001 for patients with liver cancer , lung , cervical and colon while there was significant differences at p< 0.05 for breast cancer , In the other hand the current results were shown that there were significant differences in the relationship between the infection of T. gondii and types of cancer for ELISA IgG test in lung cancer , uterus , colon , while there was not observed significant differences in both breast and liver cancer , the highest percentage for toxoplasmosis was in the lung cancer 68% and the lowest was 43.82% in breast cancer For acute infection the highest percentage rate was in colon cancer (28.57% ) and the lowest was in lung cancer patient (12%) and there were significant differences for each of liver ,lung ,uterus, breast ,colon cancer.
Keywords
Toxoplamosis; Cancer Patients; Antibodies IgG; IgM; IgG

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