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The Decrement of Glutathione Peroxidase Activity Associated with the Elevated Diene Hydroperoxide Levels in Serum of Patients with Diabetes Mellitus Type I | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 7, Issue 3, 2007, Pages 152-160 PDF (0 K) | ||
| Authors | ||
| Lamia A. M. Al Mashhedy; Mahmoud H. Hadwan; t T. Khalil; | ||
| Abstract | ||
| The glutathione peroxidase, vitamin E and dienhydroperoxide in serum were investigated in 30 subject with Type 1 (insulin-dependent) diabetes mellitus and in 30 healthy others. The mean conjugated hydroperoxide(CDH) value in the serum of diabetic patients were significantly higher than those in the control subjects (conjugated dienhydroperoxide p<0.01). The Glutathione peroxidase activity and the levels of Vitamin E significantly decreased(GPx p<0.05 while Vitamin E p<0.01). These data suggest that hyperglycemia induces oxidative stress in sera of patients compared with healthy controls and that antioxidants which used in the study are effective against oxidative injury. | ||
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