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Control of recurrent oro-labial herpes simplex lesions by in vivo enhancement of salivary peroxidase system | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 22, Issue 1, 2010, Pages 35-41 | ||
| Authors | ||
| Rajaa Al-Joubori; Ihsan A. Kameel | ||
| Abstract | ||
| ABSTRACTBackground: Many studies have been conducted to enhance the salivary innate defense factors against bacteria;this study was conducted to enhance the salivary natural peroxidase system in vivo to prevent recurrent herpessimplex type 1 infection.Subjects and methods: This study had been carried out on 40 healthy subjects (mean age 22), who were sufferingfrom recurrent oro-labial lesions. A mouth rinse was made to stimulate the salivary peroxidase system to producehypothiocyanite (OSCN-) at an antimicrobial level; the rinse was tried on 30 subjects for 100 days, while the rest werethe control.Results: It had been shown that the use of the rinse led to generation of OSCN- ≥ 100 μM which was highly efficient inreducing recurrent oro-labial herpes simplex lesions in study group.Conclusion: The properties of a mouth rinse that increases the in vivo generation of salivary OSCN- are: H2O2 3 mM,KSCN 1 mM in PBS pH 5.5, the rinse volume is 5 ml and the time of rinsing is 2 minutes.Key words: recurrent oro-labial herpes simplex lesion – peroxidase system. J Bagh Coll Dentistry 2010; 22(1):35-41. | ||
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