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The role of lipid peroxidation in the inducation and progression of chronic periodontitis | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 21, Issue 1, 2009, Pages 70-73 | ||
| Author | ||
| Taghreed F. Zaidan | ||
| Abstract | ||
| ABSTRACTBackgrounds: Free-radical-induced lipid peroxidation has been implicated in the pathogenesis of severalpathological disorders. This study was aimed to assess the degree of oxidative stress in patients with chronicperiodontitis by estimation of plasma and saliva lipid peroxidation product malondialdehyde (MDA), and theantioxidants erythrocyte glutathione (GSH), plasma and saliva thiol.Patients and methods: Fifty patients with chronic periodontitis with mean age of 32.6 ± 10.3 years and fifty healthycontrol subjects with normal gingival age study, 5 mls of blood and 3 mls of unstimulated saliva was collected fromeach subjects for estimation of plasma and saliva MDA, thiol and erythrocyte glutathione spectrophotometricaly.Results: The results showed that significantly increased p<0.001 in periodontitis patient than in the control subjects,while erythrocyte glutathione, plasma and saliva thiol were significantly decreased p<0.05 in periodontitis patientsthan in the control.Conclusions: Patients with periodontitis demonstrate more lipid peroxidation than healthy subjects. Imbalancebetween oxidative stress and antioxidants may play a role in the pathogenesis of perodontitis.Key words: Periodontitis, lipid peroxidation, antioxidants. (J Bagh Coll Dentistry 2009; 21(1): 70-73) | ||
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