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Evaluation of Brain Natriuretic Peptide levels in Sera of Iraqi Patients with Hyperthyroidism and Hypothyroidism | ||
| Kerbala Journal of Medicine | ||
| Article 1, Volume 10, Issue 2, 2017, Pages 2767-2770 PDF (0 K) | ||
| Author | ||
| Zinah Abbass Ali | ||
| Abstract | ||
| b ackground: The thyroid gland is an endocrine gland that is normally positioned in the lower neck. Cardiovascular alteration that coexist with thyroid gland diseases could trigger off the secretion of Brain natriuretic peptide from heart. Stress environment conditions and various factors have an important thumb in pathogenesis of thyroid gland diseases and may possibly eventuality lead to this reply. Volume expansion and pressure overload stimulated Brain Natriuretic Peptide secretion from the ventricular myocardium. Aim: To evaluate the role of thyroid disorders in stimulating ventricular myocardium's to screate Brain natriuretic peptide. Materials and Methods: Serum Brain Natriuretic Peptide determined by enzyme- linked immunosorbent assay (ELISA). About 36 Iraqi patients with primary hyperthyroidism and primary hypothyroidism and Twenty two subjects who are apparently healthy were enrolled in this study. Results: Serum levels of BNP hormone showed a significant elevation in hyperthyroidism as compared with control (p<0.01) and significant decrease in hypothyroidism group compared with control group. The results revealed a significant positive correlation between T3, T4 and BNP level in patients with hyperthyroidism while there was no weighty relation between the corresponding thyroid hormones and BNP level in patients with hypothyroidism. Discussion: A raise in cardiac output, total blood volume, left ventricular end-diastolic volume (LVEDV) and heart rate in hyperthyroid status exerts the “stress” of the cardiac muscles and could be potential stimuli for the emission of BNP. Conclusion: the measurement of BNP is mine important in patients with hyperthyroidism compared with the cases of hypothyroidis. | ||
| Keywords | ||
| Brain natriuretic peptide; diastolic volume | ||
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