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Protective effect Ethanol extract of Nigella sativa. L on hepatic damage induced by naphthalene in male rats | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 12, Issue 2, 2012, Pages 1-8 PDF (0 K) | ||
| Author | ||
| Zena Muhammad Hamad | ||
| Abstract | ||
| Oxidative stress with subsequent production of reactive oxygen species has been postulated as one of the mechanisms of naphthalene toxicity . In the present study ,the effect of oral administration of the natural antioxidant and free radical scavenger , alcoholic extract of Nigella sativa (300mg/kg),has been investigated in rats following the concomitant administration of naphthalene (1g/kg)and measured of selective parameters indicative of liver function .Serum alanine aminotransferase (ALT), alkaline phosphates (ALP), and total protein(TP) . Naphthalene hepatotoxicity was evident by the significant elevation of rats serum activities of ALT,ALP, and significant depression of TP .on the other hand ,concurrent administration of alcoholic extract of Nigella sativa significantly attenuated the naphthalene-induced disturbances in serum liver function enzymes , and significant elevation of TP. In conclusion ,that alcoholic extract of Nigella sativa appears to be a potent candidate to ameliorate the oxidative stress and hepatotoxicity associated with naphthalene in rats and change in some biological markers related to liver disease. | ||
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