Investigation of the Association between Serum Concentrations of Tumor Necrosis Factor-alpha (TNF-α) and Hematological Parameters in Rheumatoid Arthritis Patients in AL-Najaf Governorate

Sabbar Alnaaly, Abbas

	Investigation of the Association between Serum Concentrations of Tumor Necrosis Factor-alpha (TNF-α) and Hematological Parameters in Rheumatoid Arthritis Patients in AL-Najaf Governorate
journal of al-qadisiyah for pure science(quarterly)
Article 1, Volume 12, Issue 3, 2012, Pages 17-31 PDF (0 K)
Author
Abbas Sabbar Alnaaly
Abstract
This study was performed to determine whether the serum concentra¬tions of tumor necrosis factor-alpha (TNF-α) are elevated in patients with rheuma¬toid arthritis (RA) and to investigate the relationship between TNF-α levels and hematological parameters in RA patients. Serum samples were obtained from 70 patients with RA who had visited the Division of Rheumatology at AL-sadder Teaching Hospital in AL-najaf City and 25 age- and sex-matched healthy controls, and the clinical parameters of disease were assessed, including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor (RF). Blood pictures were performed using automated hematology analyzer Mythic™. Serum concentrations of TNF-α were measured using an enzyme-linked im¬munosorbent assay (ELISA). Serum concentrations of TNF-α, was significantly elevated in patients with RA compared to those of healthy controls. Although there was no significant rela¬tionship between TNF-α levels and RBC, Hb, HCT and red cell indices, the TNF-α levels of pa-tients with RA showed a significant correlation with total leukocyte count (TLC), differential leukocytes and platelets. It has been concluded that the serum concentrations of TNF-α was sig¬nificantly elevated in patients with RA and strongly correlated with hematological alterations. These findings suggest a possible role for TNF-α in the pathogenesis of RA.

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