- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Overcoming the antimicrobial fasting property of the dormant Brucella by combining bacterial reactivators and antiBrucella drugs in mice | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 11, Issue 1, 2011, Pages 117-123 PDF (0 K) | ||
| Author | ||
| Hussein AbdulKadhim A | ||
| Abstract | ||
| Brucella is one of the microorganism that is characterized by its ability to persist although an effective immunity and a course of antimicrobial are provided. Brucella dormancy is the major contributor for this persistence.For this reason brucellosis gains its clinical significance as recurrent disease.In a trial of overcoming this dormancy state immunity of the tested mice(induced with intraarticular brucellosis) has been modulated with short course of dexamethasone to enhance Brucella suscebtabilty to antimicrobials. Sensitive thermometer was used to evaluate the average topical left knee joint hotness in response to treatment. Evaluation of knee joint aspirate every 3 days for the average count of PMN and MN inflammatory cells in addition to the number of the stained Brucella bacilli per high power field light microscope in addition to autopsy histopathological sectioning of the leftkneejointdirectlyafterthe10 days.Mice joints temperature have been measured and showed an obvious and statistically significant increased in temperature in untreated mice(40.1 degrees at the end of monitoring course) whereas a less sharp raise noticed in dexamethasone plus doxycycline plus SMS-TM ( slfamethoxazole – trimethoprim) treated group which was lesser even than antimicrobial only treated group. There was a statistically significant decline in the number of knee joint inflammatory cells in group C as compared with the standard treated and untreated groups at P<0.05. A Brucella count in untreated mice was the largest 3400 at the end of the course in comparison with negligible count noticed in group C at the end of treatment. | ||
|
Statistics Article View: 226 PDF Download: 73 |
||