Evaluation of C- Reactive Protein (CRP) Titer in Patients with Acute Hepatitis A Virus Infection

Amer Taha, Tamara

	Evaluation of C- Reactive Protein (CRP) Titer in Patients with Acute Hepatitis A Virus Infection
journal of al-qadisiyah for pure science(quarterly)
Article 1, Volume 11, Issue 1, 2011, Pages 20-29 PDF (0 K)
Author
Tamara Amer Taha
Abstract
This study was conducted from 5th September 2008 to 15th April 2009 . in Public Health Laboratory and learning Baquba Hospital to determine the C- reactive titer among patients with acute hepatitis A virus (HAV) infection in relation to healthy subjects . the study also aimed to correlate these titers with liver function test parameters and also to findout the validity of C- reactive protein titers as diagnostic or monitoring markers in patients with acute HAV infection . The study was included 108 patients with HAV infection and 115 apparently healthy individuals were enrolled as a control group . Patient group involved 47(43.5%) female and 61(56.5%) male in age rang from (3month – 17) years . Control group include 66(57.4%) female and 49(42.6%) male in age range from (18 month – 20) years . Blood samples were collected . Sera were separated and stored in aliquts at (-20ْC) till use .The diagnosis of acute HAV infection was based on detection of IgM HAV Antibodies by ELISA technique , whereas ,liver function tests were assessed by enzymatic biochemical procedures . Titration of C- Reactive protein was determine by semi – quantitative tube agglutination test . All data were statistically analyzed using computerized SPSS version 10 .The results showed that were a significant variation (P< 0.001) between patients with HAV infection (1:64) and control( 1 : 2) when use (Mann – Whitney ) test.Depending on 95% , the baseline titer of CRP in healthy controls was 1:4 (8 mg / L) . While inpatient with acute HAV infection was 1:512 (1024 mg / L ) . The validity of CRP test at titer 1 :16 cut – off value (32 mg / L) was found highly sensitive (100%) and highly specific (97.3%) with test accuracy (98.6%) for differentiating between healthy controls and patients with HAV infection when the clinical suspicion is 50% .The results revealed that the CRP titers were significantly correlated with liver function test parameters . Suggesting that CRP titration could be used as a surrogate marker in prediction of acute HAV infection beside the clinical picture .

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