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Effect of toxicity of fluoride and treatment with calcium in liver and kidney of rabbits males | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 11, Issue 1, 2011, Pages 19-29 PDF (0 K) | ||
| Author | ||
| Hashim M. Abdul-kareem | ||
| Abstract | ||
| 30 local adult male rabbit were used in this experiment .The animals were treated with oral swallow for twelve of weeks . The animals divided to five groups : control group is oral treated with 0.9% normal saline , first treated group is treated with 10mgkg of body weight sodium fluoride , 2nd treated group is treated with 20mgkg of body weight sodium fluoride , 3rd treated group is treated with 10mgkg of body weight sodium fluoride and calcium chloride , 4th treated group is treated with 20mgkg of body weight sodium fluoride and calcium chloride . This experiment studied the histological changes in kidney and liver The kidney tissue of the animals treated with sodium fluoride at the concentration 10,20 mgkg of body weight appear mild blood vessel congestion , shrinkage in glomeruli , disturbed in renal tubules and erode its epithelium with some apoptosis , treatment with sodium fluoride and calcium chloride at the concentration 10,20 mgkg of body weight appear simple changes and hemorrhage in glomeruli , small dilation in renal tubules and erode to its epithelium with appearing inflammatory cells . The liver sections appeared appreciable effect with fluoride at the concentration 10,20 mgkg of body weight include dilation in central vein and erode to its epithelium , congestion in hepatic sinusoids with apoptosis and erode to general structure of liver , while the treatment with sodium fluoride and calcium chloride at the concentration 10mgkg of body weight appeared small effect include simple congestion in central vein , small dilation in the sinusoids with some of inflammatory cells and death in some of cells . | ||
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