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Isolation of antibiotic , antitumer alboZ from local isolates Strepyomyces alboflavus and improving its production | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 11, Issue 2, 2011, Pages 46-65 PDF (0 K) | ||
| Authors | ||
| ; A. Al-Sulami | ||
| Abstract | ||
| The ntibiotic alboZ was isolated and purified from culture broth and mycelium of Strepyomyces alboflavus. alboZ has abroad spectrum of antimicrobial activity against Gram-positive and negative bactreria . Studing the physical and chemical propereties of antibiotic were studied used thine layer chromatography , IR-spectrum ,UV-spectrum ,NMR-spectrum and suliability .Minimum inhibitory concentration was tested against five isolates of Gram positive and negative bacteria .toxic effect of the alboZ determined by LD50 of labrotory animals .Testing of the antitumor activity showed that the antibiotic antitumor activity through its induction of prophage ( λ phage).Two mutants from the exposure to gama radiation and EMS were obtained(S.alboflavus γ2 and S.alboflavus γ2E200 ), these mutants exhibited amaximum production of 1.5 and 3 g /L of antibiotic compared with wild isolate which of 1 g/L. | ||
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