Histopathological changes of secondary  metabolites of Aspergillus fumigatus isolated from  Lens culinaris grains in albino mice.

Adnan,; W.AL-Bideri,

	Histopathological changes of secondary metabolites of Aspergillus fumigatus isolated from Lens culinaris grains in albino mice.
journal of al-qadisiyah for pure science(quarterly)
Article 1, Volume 11, Issue 2, 2011, Pages 66-75 PDF (0 K)
Authors
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Abstract
The study aimed to elucidate the effects caused by secondry metabolites of Aspergillus fumigatus that isolated from Lens culinaris grains in albino mice. The results showed that percentage of Lens culinaris grains contaminated by fungi was 80 % and percentage of contamination by Aspergillus fumigatus was 61%.Three groups of animals were used in this study. The first group treated by secondry metabolites of above fungi ,the second and third group used as controls groups .The results showed that these products caused considerable pathogenic effects in liver tissue of treated animals including congestion of liver sinuses ,vascular congestion , collagen fibers aggregate and Focal Aggregate of Inflammatory cells in liver tissue ,necrosis of liver cells , small nuclei intensely stained ,lost of normal structure of liver and replacement of liver cells by fatty vacuoles ,while there were no effects in control groups( A and B). The determination of relative flow (Rf) of secondary metabolic products of fungi by ultra violate in wave 365nm ,showed that there were nine separated compounds each of one had differential color characters. Five from these compounds which had (Rf) 0.14.40,0.49,0.61,0.97 Fumigaclavine –c ,Verruculogen ,A urasperone –c ,Oxidized gliotoxin and Reduced gliotoxin respectively were determined in previous studies ,while the four compounds which had (Rf)(0.66,0.69,0.92,0.99) were not determined their physical and chemical nature and also their pathogenic effects in laboratory animals .The precent study concluded that contaminated Lens culinaris grains caused sever pathogenic effects in laboratory animals. .

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