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Preparation of Polymeric Matrix Structures and Study their Controlled Release of Glipizid (In vitro) | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 11, Issue 3, 2011, Pages 78-86 PDF (0 K) | ||
| Author | ||
| Oraas Adnan Hatem | ||
| Abstract | ||
| The Glipizide tablets which used in this study was available in the commercial local pharmacies. Glipizid material was isolated and refined, then the meltingpoint and (λmax) were determined.The gelatin and poly vinyl alcohol hydrogels wereprepared by chemical crosslinkage using glyceraldehydes.In this study several tablets were prepared as polymeric matrix systems from gelatin-PVA which loaded by Glipizide in ratio (25%, 34%, 50% wt/wt).The effect of pH on release rate of Glipizide in (PBS, pH=7.4), SGF , and SIF has been studied.The results exhibit that the pH have a great effect on releaserate of Glipizide from polymeric matrix, so the samples gave a high release rate in low values of pH (SGF & SIF) in comparison with neutral solution (PBS, pH=7.4). The results also shows that the release rate increase when the drug loading rate increase according to recent research.The study consist on the toxicity of these materials which is shown that these materials are nontoxic. The swelling behavior of prepared samples has been studied and the result show an increase in swelling ratio at low pH value | ||
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