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The Effect of Some Doses of Prostaglandin E1in Spermatogenesis in white rats Rattus rattus | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 11, Issue 3, 2011, Pages 62-77 PDF (0 K) | ||
| Author | ||
| Haider Kamil Zaidan | ||
| Abstract | ||
| spermatogenesis in adult white male rats (Rattus rattus) after treated by mouth. 60 males from white rat were used divided randomly into three main groups each one of them contained 20 individuals of animals were treated for 2 , 4 & 6 days with prostaglandin E1(PGE1). Each main group was divided randomly for 4 subgroups, each subgroup contained 5 animals treated by solution of 0.9% NaCl , 10 , 20 & 30 µg/kg of body weight of PGE1. The weights before treatment and after 24 hours from the last dose of treatment were measured, and also testes of animals were weighted after they were removed and the histological sections were prepared for studying the effecting of the PGE1on the mean of the numbers of spermatogenic cells , Sertoli cells , the diameter and percentage of seminiferous tubules that were damaged and were compared with control groups. The results were:- Significant and nonsignificant results were occurred in different groups that treated with different doses and concentrations of PGE1. Significant decrease (P<0.05) happened in mean of number of sertoli cells of animal’s groups that treated 2 , 4 and 6 days from 20 , 10 and (20 , 30) µg/kg of body weight PGE1 in prospectively. Some time significant increase and another time significant decrease had occurred in mean diameter of seminiferous tubules depend on doses and concentrations. The means of percentage of number of seminiferous tubules that damaged were increased significantly (P<0.05) in all groups that treated by PGE1 depend on period and concentration of dose, however, observed significant changes (P<0.05) in mean of weight of animal gonads treated with PGE1 comparison with the control group. In conclusion : the administrated PGE1 influenced on spermatogineses dependent on the period and concentration of dose | ||
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