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The Effect of Ellagic Acid Extract from Hibiscus Sabdariffa on Sera of Leukemic Patients | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 10, Issue 2, 2010, Pages 75-85 PDF (0 K) | ||
| Author | ||
| Wasan Abd Al-Karim M | ||
| Abstract | ||
| Recent clinical studies have confirmed that ellagic acid (EA) , a naturally occurring plant polyphenol found in various fruits and vegetable, has exhibited anticarcinogenic activity in both in vitro and in vivo systems. In the present study a light on oxidant- antioxidant status was sheded in 45 patients with two types of acute lymphocytic and myelocytic leukemia (ALL and AML) in addition to twenty healthy as control group .The work consist of two parts: 1- Extraction Part which included extraction and identification of EA from Hibiscus Sabdarilfa (HS) the terrestrial plants. The results were proved by thin layer chromatography (TLC) and UV-VIS spectrophotometry. 2- Clinical Part which included evaluation of some parameters in vitro studies in all leukemic patients compared to control group: I- Evalution of malondialdehyde (MDA), lipid peroxidation marker, and caeruloplasmin (CP): The results illustrated significant elevation in both malondialdehyde (MDA), and caeruloplasmin (CP) in all leukemic patients compared to control . These elevation decreased to about normal values by treatment with 10 μL(10-5 M) ethanolic ellagic acid which extracted from HS. The effect of ethanol which used as solvent was found to be negligible. II- Evalution of serum transferrin . A decreased in transferrin levels was found in leukemic patients compared to healthy subjects. The levels of TF elevated into normal values by treatment with 10 μL ethanolic ellagic acid. | ||
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