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Biochemical study of Ascorbic Acid derivatives as a pro_drug | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 10, Issue 3, 2010, Pages 25-33 PDF (0 K) | ||
| Authors | ||
| ; Firas A.Hassan | ||
| Abstract | ||
| In this research new derivatives of L-ascorbic acid (vitamin C) have been synthesized. These derivatives have been obtained by the esterification. Selective esterification of C-3 and C-2 hydroxyl group required protecting the two hydroxyl groups at 5-6-position by conversion of vitamin C to 5-6-O-isopropylidene derivative (I). 3-(acetyl salicyloyl)-5-6-O- isopropylidene-L-ascorbic acid (III) was synthesized by treatment of (I) with acetyl salicyloyl chloride (II). The purity of the compounds were characterized by thin layer chromatography (TLC) and infrared spectroscopy (IR). The Kinetic study for compounds (1,3) was carried out using different buffer at pH (4,8) over 30 hours at different intervals of periods using UV spectroscopy which showed that these compounds were hydrophobic. The released aspirin was increased as the pH is increased and extended time. | ||
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