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Ellagic Acid ( Pomegranate Extract ) as Potent Antioxidant for Myocardial Infarction (MI) in vitro Study | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 10, Issue 3, 2010, Pages 11-16 PDF (0 K) | ||
| Author | ||
| Dr.Zeinab M. Al-Rubaee | ||
| Abstract | ||
| The production of reactive oxygen species in most diseases including heart disease is confirm to be the most destructive process to human cell. Potent antioxidant is needed to overcome the lipid peroxidation and oxidative strees. The effect of ellagic acid (EA) [ pomegranate extract ] on some metabolic enzymes were investigated in patients with myocardial infarction(MI). Two ml of venous blood was obtained from thirty patients (10 male&20 female) with MI and 30 healthy individuals (10 male&20 female) as control group, the age of both genders range from 40-65 years. Serum used to determined activities of creatine kinase(CK), aspartate transaminase (AST) and alanine transaminase(ALT). Elevated values of CK, AST and ALT activities in patient’s were found (368.66± 66.63 , 90.93±13.8 , 97.83± 32.76) respectively. These activities returned to about normal values after addition of 10 μM ellagic acid (250± 72.07 , 58.3 ±14.48 , 64.77± 20.26 ) respectively.The results demonstrated no significant difference in results between the both genders. A conclusion of the present study revealed the effectiveness of ellagic acid in treatment of patients with MI invitro study which ellagic acid act by different mechanisms to protect and prevent heart diseases. | ||
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