Serum and salivary levels of proinflammatory cytokines as potential biomarkers in the diagnosis of oral squamous cell carcinoma

R. Hamad, Abdul-Wahab; M. Gaphor, Shanaz; G. Al Talabani, Nazar

	Serum and salivary levels of proinflammatory cytokines as potential biomarkers in the diagnosis of oral squamous cell carcinoma
Journal of baghdad college of dentistry
Article 1, Volume 21, Issue 1, 2009, Pages 60-65
Authors
Abdul-Wahab R. Hamad; Shanaz M. Gaphor; Nazar G. Al Talabani
Abstract
ABSTRACTBackground: Oral squamous cell carcinoma is one of the prevalent cancers of the body . If not treated at its earlystages, the prognosis will be poor. Early diagnosis of oral cancer may not be easy clinically because of itsresemblance to a number of benign lesions in the mouth. The aim of the study was to evaluate the validity ofmeasurement of some proinflammatory cytokines levels in serum and saliva as biomarkers for early detection of oralcancer.Materials and methods: The levels of Interleukins IL-1α, IIL-6, IL-8 and Granulocyte Macrophage-Colony StimulatingFactor (GM-CSF) in the serum and saliva of (30) patients with OSCC and (20) healthy (control) individuals weremeasured by enzyme linked immunosorbent assay (ELISA).Results: Higher concentrations of serum IL-6 and IL-8 levels were observed in patients with OSCC than the controlgroup (P<0.001). No significant difference was seen in serum IL-1 alpha and GM-CSF between patients with OSCCand control group. The levels of IL-1 alpha, IL-6, IL-8 and GM-CSF in saliva showed significant increase in patientswith OSCC when compared with control group.Conclusion: It is concluded that the levels of certain prinflammatory cytokines can be measured in serum and salivaof patients with OSCC and healthy individuals. Detection of increased levels of these elements can be used asbiomarkers for early detection of oral cancer,Keywords: oral cancer; saliva, serum, cytokine, interleukine. (J Bagh Coll Dentistry 2009; 21(1): 60-65)

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