Preparation one of prodrug and study its effect on some biochemical parameters at blood serum

S. Abdul-Razzak, F.; M.Najim, D.

doi:10.32894/kujss.2016.131061

	Preparation one of prodrug and study its effect on some biochemical parameters at blood serum
Kirkuk Journal of Science
Article 1, Volume 11, Issue 4, 2016, Pages 33-55 PDF (0 K)
DOI: 10.32894/kujss.2016.131061
Authors
F. S. Abdul-Razzak; D. M.Najim
Abstract
This study included synthesis of Tri [2(4-isobuty phenyl) propionyl ] glycerate afforded by reaction of Glycerol with Ibuprofen. The purification of the synthesized derivative was established by (TLC) and column chromatography while the structure suggesting was confirmed by ( FTIR ، 1H-NMR ) and the result obtained given good evidence for structure proposed to their compound and using through the study groups , and take (36) rabbits proximate in the weight and divided into four groups contain of (9) rabbits . the first group used as acontrol group and the second group dosed with synthesized compound ( 50 mg/kg ) and the third group dosed with the solvent used (DMSO) ,and the fourth group dosed with Ibuprofen drugs. After (3)hours from doses withdrawal blood sample and serum was isolated and Conducted study By biochemical and enzymatic variables. Variables included measurement enzyme activity following (Cholinesterase(ChE) were also measured the concentration of each of the (Total fucose, Fucose bounded protein,Hexoses bounded protein ) statistical data analysis: revealed signification increase in the activity of Cholinesterase ، signification increase in level total fucose,Protein bounded fucose , and signification decrease in level concentration protein bounded Hexoses ,and signification increase in level concentration , and this study included the hydrolysis of compound at different pH(acidic and basic) and the results showed that the compound hydrolyzed at basic medium faster than acidic medium.
Keywords
prodrug; Ibuprofen; Glycerol

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