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Effect Over Dose of Metformin Drug in Pregnants White Mice Mus Musculus liver | ||
| Kirkuk Journal of Science | ||
| Article 1, Volume 12, Issue 3, 2017, Pages 101-115 PDF (0 K) | ||
| DOI: 10.32894/kujss.2017.131308 | ||
| Authors | ||
| Asmat Jamal Jameel; Aziz Khalid Hamid; Faeza Nasir Toama | ||
| Abstract | ||
| The study included the effect of metformin drug over dose in the liver pregnant non – Diabetic mice with weight ranged (25±2) gm , Orally administration of ( 1.8 , 2.85) mg of drug from (6-18)th day of pregnancy in the morning and once time daily, Drug caused death in half number of animals in 1.8) ) mg concentrate and caused significant increase in liver weight in high concentration 2.85 mg and non significant in low concentration compared with control group ( non treated ) , In addition some histologically changes that included inflammatory cells around damaged blood vessels which increase with high dose caused primary biliary cirrhosis . Other changes include Degeneration , necrosis , Blood vessels damage ,Greenish, Congestion and hemorrhage and fibrosis in the liver of dead mice . | ||
| Keywords | ||
| Metformin drug; Pregnant Mice; Death animals; Histological changes | ||
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