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Effect of Therapeutic dose of Metformin drug in Blood Sugar Pregnant Mice Treated With Folic Acid | ||
| Kirkuk Journal of Science | ||
| Article 1, Volume 12, Issue 3, 2017, Pages 133-144 PDF (0 K) | ||
| DOI: 10.32894/kujss.2017.131310 | ||
| Authors | ||
| Asmat Jamal Jameel; Aziz Khalid Hamid; Faeza Nasir Toama | ||
| Abstract | ||
| The study include effect therapeutic dose of metformin drug in blood sugar of pregnant mice treated with folic acid . Mice weight ranged (25±2) g with age (12-16 )weeks ,The concentrations of uesd were ( 0.18 & 0.53 ) mg 25 gm mice body weight which corresponded to (500&1500) mg70 Kg of body weight in adult human , The therapeutic dose of folic acid used was ( 0.002 ) mgmice body weight which corresponded to ( 5 ) mg body weight in human , was aimed to define the effects of drugs in sugar level during pregnancy with the presence of folic acid or its absence , The drug was orally administrated , at (6-18)th day of pregnancy while folic acid was administrated at ( 4-18) th day . This group was treated with metformin drug after 2 hours of folic acid admimstration at (6) th day , The administration was once in the morning of each , The results showed non significant decrease in the sugar level in groups treated with metformin while significant increase in groups treated with metformin drug and folic acid compared with control. | ||
| Keywords | ||
| Metformin drug; Folic acid; Polycystic Ovaries Sydnrome | ||
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