Lactate dehydrogenase in serum and saliva of ischemic heart disease patients

A. Mahmood, Rehab; F. Zaidan, Taghreed; M. Shaheed, Alaa

	Lactate dehydrogenase in serum and saliva of ischemic heart disease patients
Journal of baghdad college of dentistry
Article 1, Volume 22, Issue 1, 2010, Pages 21-24
Authors
Rehab A. Mahmood; Taghreed F. Zaidan; Alaa M. Shaheed
Abstract
ABSTRACTBackground: Lactate dehydrogenase (LDH) is an enzyme detectable in cytoplasm in almost every cell of thehuman body, which becomes extracellular upon cell death. Therefore, its extracellular presence is always relatedto cell necrosis and tissue breakdown. The aim of this study was to assess LDH in ischemic heart diseased patientsand chronic periodontitis patients and to assess the role of saliva as a diagnostic tool for this biochemical analysis.Materials and Methods: One hundred and forty individuals were enrolled in this study; forty of them were patientshaving ischemic heart diseases (IHD); sixty patients were age and sex matched risk groups (thirty patients withhypertension and thirty with diabetes mellitus type 2); the last group was age and sex matched apparentlyhealthy control individuals. Serum and saliva samples have been taken from each subject for LDH analysis.Periodontal status have been determined using the clinical periodontal sum score (CPSS).Results: the mean activity of serum LDH was significantly higher in IHD patients compared to healthy controls & riskgroups, while salivary LDH was highest in relation to highest score of chronic periodontitis (CPSS).Conclusions: Serum LDH is highly significant in predicting IHD patients, while salivary LDH increases with chronicperiodontitis progression.Key words: Ischemic heart diseases, chronic periodontitis, and Lactate dehydrogenase (LDH). J Bagh CollDentistry 2010; 22(1):21-24.

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