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Spectrophotometric Determination Mefenamic Acid , in Pharmacutical Preparation by oxidative coupling 2,4,dinitrophenyl hydrazine by N-bromo succinmide | ||
| Kirkuk Journal of Science | ||
| Article 1, Volume 12, Issue 3, 2017, Pages 649-666 PDF (0 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.32894/kujss.2017.131503 | ||
| Authors | ||
| Raghad Ali hamed Al dehema; Mohsin Hamza Bakir | ||
| Tikrit University – College of Education for women | ||
| Abstract | ||
| This eserech includes the development of spectrophotometric method for determination of mefenamic acid via oxidative coupling with the 2,4,dinitrophenyl hydrazine reagent in presence of oxidizing agent N-bromo succinmide in the alkaline medium to form a colored-dye red, which dissolved in water and showed the highest intensity of absorption at λmax 528 nm. The method has been obeyed Beer's law in the concentration range 2-8 µg.ml-1, with molar absorptivity of 3.6873 ×104 L. mol-1. cm-1, Sandel Index value 0.006535 µg.cm-2, the detection limited 0.011 µg.ml-1, with correlation coefficient 0.992. The relative standard deviation of the method does not exceed 2.27%. The proposed method was applied successfully for the determination of Mefenamic acid in tablets by both the direct and standard addition methods, the recovery ranged between 99.3-100.2%. | ||
| Keywords | ||
| Oxidative Coupling; bromo succinmide | ||
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