Isolation, Characterization and Estimation of Ellagic Acid activity against Porphyromonas gingivalis Isolated from adult Periodontitis Patients in Kerbala City.

Alnasrawy,; A.A,; Y.A,; Al-Khafaji,; Altmimy,; F.M,; Alnasrawy,; M.S,

	Isolation, Characterization and Estimation of Ellagic Acid activity against Porphyromonas gingivalis Isolated from adult Periodontitis Patients in Kerbala City.
karbala journal of pharmaceutical sciences
Article 1, Volume 6, Issue 9, 2015, Pages 16-29 PDF (0 K)
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Abstract
Periodontitis is a chronic bacterial infection affects the gingiva, periodontium connective tissues and alveolar bone, results in alveolar bone resorption, ultimately, partially or completely tooth loss, indeed, it may causes various serious systemic complications like Diabetes Mellitus, Cardiovascular disorders, Rheumatoid Arthritis, Preeclampsia with low birth weight and Orodigestive cancer mortality. Porphyromonas gingivalis is considered the main, foremost and strongest periodontal pathogen. Isolation, characterization and monoplex PCR of 16S rRNA and multiplex PCR of fimA geneotyping are the golden standard assays for detection of P.gingivalis in adult periodontitis patients. In the present study,Pomegranate peel Ethanol extract partially purified ellagic acid has an obvious effectiveness against oral pathogens (P. gingivalis and S. mutans) in both growth inhibition zone on solid medium and Percentage of growth reduction in a liquid medium in various concentrations with common MIC 16mg/ml.
Keywords
periodontitis; Isolation and characterization of Porphyromonas gingivalis; S rRNA; fimA genotyping; Ellagic acid

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