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Evaluation of Cancer Antigens (CA125&CA153-) in some Iraqi women with polycystic ovarian syndrome | ||
| Iraqi Journal of Embryos and Infertility Researches | ||
| Article 1, Volume 3, Issue 6, 2013, Pages 11-14 | ||
| Authors | ||
| Zainab Faeiq Rzaij; Nawal Khairy Hussain AL-Ani | ||
| Abstract | ||
| Background: Polycystic ovary syndrome (PCOS) is the most common cause of hyperandrogenism anovulatory infertility; it affects 510- % of females in the reproductive age. PCOS is a risk disease; it has an association with gynecological malignancy. Objectivs: To determine whether Cancer Antigen 125 (CA125) and Cancer Antigen 153-(CA153-) levels are increased in PCOS and possibility of CA125 and CA153- to be used as a diagnostic marker of PCOS Methods: Seventy females with PCOS diagnosed depending on three criteria : Menstrual history of oligomenorrhea , ultrasound examinations revealed polycystic ovaries and biochemical hyperandrogenism. Twenty normal fertile females serve as control group. Blood samples were obtained from all individuals from 2nd-4th day of menstrual cycle to measure levels of FSH, LH and testosterone .Second blood samples were collected from the same patients during late follicular phase to measure CA153- and CA125( by ELISA) . Results: Females with PCOS and controls differed significantly(p<0.05)intotalserumtestosterone(p).Females with PCOS and controls have highly significantdifference(p<0.001) inLH meanlevel(7.881.83+ vs 3.900.73+ ) respectivelyand, highly significantdifference(p<0.001) inLH/FSHratioand BMI parameters. No significantdifferences(p>0.05)werefoundinFSH,CA125andCA153- between PCOS patients and the controls.There were positive correlation between testosterone and CA125.Negative correlation between testosterone and CA153- serum values. Conclusion: There were no changes in the serum levels of CA125andCA153- in PCOS patient at the age of reproduction and those cancer antigens could not be used as diagnostic markers for polycystic ovarian syndrome. | ||
| Keywords | ||
| PCOS; Testosterone; and FSH | ||
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