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Formulation of telmisartan microsponge tablets and In-Vitro evaluation of dissolution profile | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 6, Issue 9, 2015, Pages 91-104 PDF (0 K) | ||
| Author | ||
| Muder AL Haydar | ||
| Abstract | ||
| Objective: The aim of this study is to formulate microsponge of telmisartan as a tablet dosage form and evaluate the release profile in comparing with Micardis® the marketed telmisartan.. Methods: Temisartan microsponge was prepared by quasi-emulsion solvent diffusion method by using polymers either Eudragite E or eudragite L in organic solution as internal phase and aqueous solution of polyvinyl povidone as external phase. Five formulations of microsponge temisartan tablet were prepared including formulation 3 which contains pure telmisartan by direct compression method. All formulations were evaluated for flowability characteristic and release profile in comparison with marketed tablet Micardis®. Results: Telmisartan microsponge was successfully formulated without any interaction or in compatibility with Eudragite polymer. The flow properties of the microsponge powder were with acceptable limit. The wetting and disintegration time of F1, F2, F4 and F5 in microsponge system were decrease in comparison to the F3 which used plain telmisartan and Micardis® a conventional tablet. The superdisintegrants crospovidone 5% which represented in formula F4 and F5 gave the rapid disintegration time compared to the other formulas. The dissolution profile of the temisartan for all formulation and comparing to the Micardis tablet indicated the improvement of the dissolution rate by using microsponge system. Conclusion: It was indicated that telmisartan microsponge was successfully formulated and their tablet formulations proved to show better release profile in all aspects as compared to marketed (Micardis®) tablet. Using of different super disintegrates have significant effect on wetting and disintegration time of telmisartan tablet. | ||
| Keywords | ||
| temisartan; superdisintegrant; microsponge; wetting time; direct compression | ||
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