- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Formulation and evaluation of clarithromycim oral microspong | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 6, Issue 9, 2015, Pages 114-123 PDF (0 K) | ||
| Authors | ||
| Jenan m. Mohsin al mosawi; laith hamza samein; alaa abdul- razzaq | ||
| Abstract | ||
| Clarithromycin is a broad-spectrum antibiotic and extensively absorbed orally. It is be used in the eradication of H. Pylori infection combined with an acid suppressing agent. The purpose of this study was to develop controlled release clarithromycin floating micro sponges for gastro retentive drug delivery. The micro sponge’s formulations were prepared by quasi-emulsion solvent diffusion method employing eudragit RS 100 as a polymer and poly vinyl alcohol (PVA) as a surfactant. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. The prepared microsponge were evaluated for angle of repose, Carr's Index ,particle size, floating time production yield, drug loading efficiency of micro sponges. Shape and surface morphology of the micro sponges were been examined using scanning electron microscopy. formulation F5 with drug to polymer ratio 8:1,10 ml of internal phase volume (ethanol: dichloromethane) and 0.25%pva solution was the best formula showing the highest degree of sustained release that is 79.59% at the end of 12 hours with floating time for 12 hr. Eudragit RS 100 could control drug release in stomach. | ||
| Keywords | ||
| Micro sponges; clarithromycin; Quasi; emulsion solvent diffusion method | ||
|
Statistics Article View: 178 PDF Download: 81 |
||