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Determination of Glimepiride, Amlodipine and Nitrofurantoin by Reversed phase - High Performance Liquid Chromatography (RP- HPLC Technique) | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 6, Issue 9, 2015, Pages 138-144 PDF (0 K) | ||
| Authors | ||
| H. H; ; I. T; | ||
| Abstract | ||
| The drugs were studied in this research are Glimepiride( GLM) is insulin independent and glucose reduction level in blood of human body ,Amlodipine (AML)is lowering blood pressure and Nitrofurantoin( NTF) is used to treat urinary tract infection. In spite of many analytical techniques were used to determine these drugs. Modified HPLC was used in present work ,this analytical technique is rapid, accurate, sensitive and applied for determination of drug in its formulations. Analytical parameters for determination of drugs GLM, AML and NTF by RP-HPLC at UV detector were as following ; mobile phas acetonitrile:water:ethanolsodiumphalate(60:20:20),cetonitrile:water:triethyamine(45:45:10), acetonitrile:buffer solution(30:70),flow rate (1.5,1.5,1.0) ml/minute, wave length (230,245,254) nm, retention time (8.169,6.771,4.413) minutes ,stationary phase C18 column, linear range 10-50, 2-10,5-25 μg/ml, limit of detection (2.8×10-5 ),(2.9×10-3),(9.3×10-3) μg/ml, standard deviation (0.054,1.8439,0.0625) and the percentage of recovery (100.06%,100.9%,100.8%) respectively. | ||
| Keywords | ||
| Glimepride; Amolodipine and Nitrofurantoin | ||
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