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Preparation of Nanohybrid antifungal from Nystatin and determination its inhibitory efficiency against Candida spp. | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 6, Issue 9, 2015, Pages 145-165 PDF (0 K) | ||
| Authors | ||
| Zahraa Shakir Mahmod; Ali Abdul Kadhim Al-Ghanimi | ||
| Abstract | ||
| A nanohybrid antifungal Nys-ZnO was prepared using sol-gel ion exchange method between the antifungal Nystatin (Nys) and Zinc Oxide. The new nanoantifungal was identified. FT-IR spectroscopy revealed the appearance of new groups in the Nys-ZnO spectrum which indicates the formation of new compound. The X-Ray Diffraction (XRD) spectrum revealed the appearance of new diffraction planes in the nanohybrid antifungal spectrum in compare with the spectrum of zinc oxide. Scanning Electron Microscope (SEM) showed the presence of some change in the Nys-ZnO surface. The two and three dimensional image of the above compound in atomic force microscope confirmed the formation of new antifungal with nanodimensions. The antimicrobial activity of the nanohybrid antifungal was studied against 23 isolates of Candida. Results showed that highest inhibition was obtained against isolate Candida tropicalis 4 with avarege inhibition zone of 24.08 mm . | ||
| Keywords | ||
| Nanohybrid; Zink Oxide; Nystatin; Biological activities | ||
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