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Synthesis Of Several New Cyclic Imides Linked To [3-Mercapto-5-(4ʹ-tolyl)-1,2,4-triazole]Moiety With Antibacterial Activity Study | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 6, Issue 10, 2015, Pages 0-0 PDF (0 K) | ||
| Authors | ||
| Ahlam Marouf Al-Azzawi; Enas Khalil Jassem | ||
| Abstract | ||
| In this work a variety of new cyclic imides containing1,2,4-triazole ring were synthesized via multisteps synthesis.In the first step,p-toluic acid was introduced in esterification reaction with ethanol,producing compound[1]ethyl-4-methyl benzoate.Introducing of compound [1]in reaction with hydrazine hydrate in the second step afforded compound[2]4-tolyl acetohydrazide.Reaction of compound[2] with carbon disulfide in alkaline medium followed by refluxing the product with hydrazine hydrate afforded compound[3]3-mercapto-4-amino-5-(4ʹ-tolyl)-1,2,4- triazole.Compound [3]was introduced in reaction with different cyclic anhydrides producing a series of new amic acids[4-8]which subsequently were dehydrated via treatment with acetic anhydride and anhydrous sodium acetate producing the corresponding target imides [9-13]. Antibacterial activity study of the new imides indicated that,they exhibit good inhibition activity againt the tested organisms. | ||
| Keywords | ||
| tolyl aceto hydrazide; cyclic anhydrides; cyclic imides | ||
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