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Synthesis and Antibacterial Activity Evaluation of Several New Sulfonamido Naphthalimides Linked to Benzothiazole or Oxadiazole | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 6, Issue 10, 2015, Pages 0-0 PDF (0 K) | ||
| Authors | ||
| Ahlam Marouf Al-Azzawi; Ahmad Solaiman Hamd | ||
| Abstract | ||
| In this work several new sulfonamido naphthalimides linked to benzothiazole or oxadiazole cycles were synthesized via multistep synthesis. The first step involved synthesis of compound [1] N-phenylnaphthalimide via reaction of aniline with naphthalic anhydride at high temperature in the presence of glacial acetic acid. In the second step compound [1] was introduced in reaction with chlorosulfonic acid producing compound [2] 4-(N-naphthalimidyl) phenyl sulfonyl chloride which inturn introduced subsequently in the third step in reaction with 2-amino-5-substituted-1,3,4- oxadiazoles producing the target naphthalimides [10, 11] or with substituted 2-aminobenzothiazoles producing the target naphthalimides [12-16]. Results of antibacterial activity study of the newly synthesized naphthalimides indicated that they posses high antibacterial activity. | ||
| Keywords | ||
| Naphthalimides; Oxadiazoles; Benzothiazoles | ||
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