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Synthesis of N- Drug MaleamideChitosan Drug polymers | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 6, Issue 10, 2015, Pages 0-0 PDF (0 K) | ||
| Authors | ||
| Firyal M.A; Saadoon A.A; Faris H.A.M | ||
| Abstract | ||
| In this research a new prodrug chitosan maleamide derivatives were synthesis via reaction of amino group of chitosan with maleic anhydride then converted to its corresponding acyl chloride, of the chitosan maleate derivative (A1) was reacted with different drug-NH2 (A2-A5) such as procaine, cephalexin, amoxicillin, and 4-aminoantipyrine.which could have potential use as a natural drug delivery system as a sustain release through hydrolysis of amide attachment in different pH values such as in acidic or basic medium. These derivatives were characterized by FTIR and 1H-NMR spectroscopies. Controlled drug release was studied using UV. Spectroscopy at λmax 270nm gave a constant swelling percentage were measured indicated controlling release with other advantages and to minimize the toxicity and the side effect. Thermal analysis such as TGA and DSC were studied indicated the thermally stableprodrug polymers. | ||
| Keywords | ||
| Poly amid; amide; Prodrug; Natural Drug Polymer; Controlled Release | ||
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