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Effect of Olea Europea ( Olive oil ) on gentamicin induced hepatorenal toxicity in male rats | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 6, Issue 10, 2015, Pages 0-0 PDF (0 K) | ||
| Authors | ||
| MOHAMMED TALAT ABBAS; ALI JELEEL ALI; IBRAHIM S.ABBAS; NEZAR METAB; HASSENEIN NOOR HADI; KASIM SAKRAN ABBAS; NEJDET ALI; Akram Abd AL- Hussein; Ayat Burhan; Tuka Hassan; Hiba Jalal | ||
| Abstract | ||
| Gentamicin is aminoglycoside antibiotic commonly used for the treatment of Gram-negative bacterial infection. In many cases, it has been the only effective therapeutic drug against bacterial strains resistant to other antibiotics, but nephrotoxicity and hepatotoxicity side effects limit its use. The aim of this study is to investigate the protective effect of olive oil against gentamicin-induced hepatorenal toxicity in male albino rats. In this study we used 24 wistar-albino rats and divided them into 4 equal groups. Each experimental group consisted of six animals. group1,control they were given normal saline only ,group2,gentamicin 100 mg/kg/day intraperitoneal (IP),group3,olive oil 5 ml/kg/day (oral administation) ,group 4,gentamicin 100 mg/kg/day intraperitoneal (IP) and olive oil 5 ml/kg/day (oral administration).Treatments were administered once daily for 21 days. After 21 days, biochemical and histopathological analysis were conducted to evaluate hepatoranal toxicity. Serum levels of urea, creatinine, cholesterol,triglyceride,and activity of AST and ALT were measured.Animals treated with gentamicin alone showed a significant increase in serum levels of these markers.Treatment of rats with olive oil showed significant improvement in renal and hepatic function , presumably as a result of decreased boichemical parameters associated with gentamicin-induced hepatorenal toxicity.Histopathological examination of the rats kidneys and liver confirmed these observations. Therefore olive oil may protect against gentamicin-induced hepatorenal toxicity | ||
| Keywords | ||
| Gentamicin; Hepatorenal toxicity; Olive oil; Rats | ||
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