F. AL-Hiti, W., J. Khammase, S., T. Mahdi, B. (2017). Preparation and Diagnosis of Pyrimidines Derivatives by Conventional And Microwave Ways.. , 10(1), 28-36. doi: 10.37652/juaps.2016.132439
Waleed F. AL-Hiti; Samea J. Khammase; Bushra T. Mahdi. "Preparation and Diagnosis of Pyrimidines Derivatives by Conventional And Microwave Ways.". , 10, 1, 2017, 28-36. doi: 10.37652/juaps.2016.132439
F. AL-Hiti, W., J. Khammase, S., T. Mahdi, B. (2017). 'Preparation and Diagnosis of Pyrimidines Derivatives by Conventional And Microwave Ways.', , 10(1), pp. 28-36. doi: 10.37652/juaps.2016.132439
F. AL-Hiti, W., J. Khammase, S., T. Mahdi, B. Preparation and Diagnosis of Pyrimidines Derivatives by Conventional And Microwave Ways.. , 2017; 10(1): 28-36. doi: 10.37652/juaps.2016.132439

Preparation and Diagnosis of Pyrimidines Derivatives by Conventional And Microwave Ways.

Journal of University of Anbar for Pure Science
Article 9, Volume 10, Issue 1, 2016, Pages 28-36    PDF (688.52 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2016.132439
Authors
Waleed F. AL-Hiti* 1; Samea J. Khammase2; Bushra T. Mahdi3
1University Of Anbar - College of Education for Women
2University of Baghdad - College of Science for Women
3University of Anbar - College of Education for Girls
Abstract
This work includes synthesis and characterization of new derivatives of pyrimidine (R. or Ar. -1, 2, 3, 4-tetrahydropyrimidin-5-yl) ethan-1-one), via the reaction of acetyl acetone with different aldehydes and guanidine hydrochloride. Using absolute ethanol as a solvent .This mixture was refluxed for (6– 20) hrs.at pH 6 we prepared .The same derivatives of pyrimidine were prepared in microwave way. This compounds were prepared characterized by melting point, FT-IR , UV-Vis and some of the with 1H-NMR and 13C-NMR spectroscopy .
Keywords
preparation; diagnosis; Pyrimidines; Conventional; microwave Ways
References
  1. Zhao, X. L., Zhao, Y. F., Guo, S.-C., Song H. S. Wangand D. and  Gong P.,(2007 ) “Synthesis and anti-tumour activities of novel [1,2,4] triazolo [1,5-a]pyrimidines”. Molecules, 12, 1136–1146.
  2. Cordeu L., Cubedo E., Bandrés  E., Rebollo  A., Sáenz  X., Chozas H., Domínguez, M.V., Echeverría, M., Mendivil, B., Sanmartin, C., Palop, J. A., Font, M. and García-Foncillas, J.(2007) “Biological profile of new apoptotic agents based on 2,4,-pyrido[2,3-d]pyrimidine derivatives. Bioorg”. Med. Chem., 15, 1659–1669.
  3. Sharma, P.; Rane, N.; Gurram and V. K. , Synthesis QSAR(2004, ) “studies of pyrimido[4,5-d]pyrimidine2,5-dione derivatives as potential antimicrobial agents. Bioorg”. Med. Chem. Lett. 14,  4185–4190.
  4. Dos Anjos J. V.  ,MendonçaJr  F. J. B., Costa-Silva J. H. ,de Souza I.A., MeloS.J. and Lat. Am. J. Pharm., (2008), 27 p. 343.
  5. White D. C., Greenwood T. D., Downey A. L.,Bloomquist J. R., and Wolfe J.  F. (2004) ,Bioorg. Med. Chem., 12, pp. 5711–5717.
  6. Dos Anjos J. V., Srivastava R. M., Costa-Silva J. H. , Scotti L., Scotti M. T., Wanderley A. G., Leite E. S., Melo S. J. and Junior F. J. B. (2012),  , Molecules, 16 pp. 809–819 .
  7. Saladino R., Ciambecchini U., Maga G., Mastromarino P., Conti C. and  Botta M. A. (2002), Bioorg. Med. Chem. Lett., 10 , pp. 2143–2153.
  8. Yamaguchi M. , Wakasugi K., Saito R., Adachi Y., Yoshikawa Y., Sakurai H., and Katoh A.  (2006), Inorg J. Biochem., 100 ,pp. 260–269.
  9. Elkholy Y. M. and Morsy M. A. Facile (2006) “Synthesis of 5,6,7,8-Tetrahydropyrimido[4,5-b]-quinoline Derivatives”. Molecules, 11, 890–903.
  10. Holla B. S., Mahalinga M. , Karthikeyan M. S., Akberali P. M. and Shetty N. S. (2006)“Synthesis of some novel pyrazolo[3,4-d]pyrimidine derivatives as potential antimicrobial agents”. Bioorg. Med. Chem. 14, 2040–2047.
  11. Ingarsal N., Saravanan G., Amutha P. and Nagarajan S. (2007) ,Synthesis, in” vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines” .Eur. J. Med .Chem. 42, 517–520.
  12. Sharma P., Rane, G. N. and Synthesis V. K. ( 2004) QSAR” studies of pyrimido [4,5-d] pyrimidine2,5-dione derivatives as potential antimicrobial agents. Bioorg. Med. Chem. Lett., 14,  4185–4190.
  13. Kandil S. S., Katib S. M.,  Yarkandi A. and Trans N. H. M. Met.( 2007) Chem., 32, 791-798
  14. Elkholy, Y. M. and Morsy M. A. , (2006) “Synthesis of5,6,7,8-Tetrahydropyrimido [4,5-b]-quinoline Derivatives”. Molecules, 11, 890–903.
  15. Augusto L. X., Alfredo M. S. , Emerson P. da S. F. and Janaína V. dos A. (2013 ) “Antinociceptive pyrimidine derivatives: aqueous multicomponent microwave assisted synthesis”Volume 54, Issue 26, 26 June, Pages 3462–3465.
  16. Ehsan S.  , Ishfaq A. , Khan B., Saghi T. and Ghafoor S.( 2012),"Conventional and Microwave – Assisted Synthesis and Antimicrobial evaluation of pyrimidine  Azo compounds" , International J.of science and research ", 3(12),P.368-373 ,.
  17. Xavier A. L., Simas A. M. ,Falcao E. S. and dos Ajos J.V., (2013. )“Antinociceptive pyrimidine derivatives :aqueous multicomponent microwave assisted synthesis” Tetrahedron Letters 54, 3462–3465 ,
  18. Srivastara V. (2013.).,"An Improved protocol for BiginelliReaction",Green sustainable Chemistry ,3,P.(38-40) ,
  19. Mitra M. and Oliver K. (2007) “Microwave-Assisted Solution- and Solid-Phase Synthesis of 2-Amino-4-arylpyrimidine Derivatives” J.  Comb.  Chem., 9 (2), pp 275–284.
Statistics
Article View: 444
PDF Download: 230


Journal Management System. Powered by iJournalPro.com