The mutation frequency A2756G for the MTR gene in patients with Congenital heart defects in the province of Dhi Qar

Rissan AL-rikabi, Hassan; Gataa AL-fartosi, Widyan

	The mutation frequency A2756G for the MTR gene in patients with Congenital heart defects in the province of Dhi Qar
Journal of College of Education for Pure Science
Article 1, Volume 7, Issue 2, 2017, Pages 120-132
Authors
Hassan Rissan AL-rikabi; Widyan Gataa AL-fartosi
Abstract
The present study aimed to detect the role of MTR gene and their relationship in the incidence of Congenital heart defects in Dhi Qar province, through the use of PCR- RFLP technique on this basis were collected 120 blood samples (from Nasiriyah heart Center) in tubes container on EDTA from patients with congenital heart defects ages ranging between (a month - 17 years) and 110 samples from healthy people ages ranging between (a month - 17 years) and saved directly at a temperature of - 20 ° C for use in the extraction DNA and the PCR technique. Resultsof statistical analysis also showed no correlation between polymorphism of the gene MTR and the incidence of congenital heart defects when compared to patients a range of comparison And each of the mutant homogenized style(AG) (OR=0.64 ; 95%CI=0.31-1.30)The style of the mutant differential (GG) (OR= 0.42; 95%CI=0.21-0.83) . It was evident from the results that females who have the mutant heterozygous (AG) has increased their risk of congenital heart defects by deference (OR = 1.86) and the period of confidence (0.65 - 5.27), and the results also showed that those who have the heterozygous differential (AG) and category age (month - 9 years) have increased the risk of congenital heart defects by teams (OR = 3) and the period of confidence (0.8 – 12). and the results showed no correlation between smoking and multiple genotypes of the gene MTR.
Keywords
congenital heart abnormalities; MTR gene; Mutation A; polymorphism; MTR

Statistics Article View: 54 PDF Download: 15