Effect of smoking on maternal serum level of Placental Growth Factor (PlGF) in threatened abortion women

Abdul Kareem Esmat, Sura

	Effect of smoking on maternal serum level of Placental Growth Factor (PlGF) in threatened abortion women
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 29, Issue 3, 2016, Pages 168-172
Author
Sura Abdul Kareem Esmat
Abstract
Background: Threatened abortion can defined as failure of pregnancy and vaginal bleeding and this occur before twentieth weeks of pregnancy Objective: To assess Placental Growth Factor level in smoker mothers with threatened abortion and normal pregnant women. Patients & Method: Case control study on seventy two women were included in this study, all women attended to Obstetrics and Gynecology department / Alyarmook hospital during period from December 2015 to March 2016.Subjects were divided into two groups (1) Normal pregnant women with gestational age between (6-12) weeks: 36 women serve as control group (2) Threatened abortion women with gestational age between (6-12) weeks with vaginal bleeding: 36 women serve as patient group. Women with cigarette smoking were included in this study. Serum samples were analyzed by using (ELISA). Results: There was significantly increasing in mean level of Placental Growth factor in smoker than non-smoker threatened abortion women group (p value <0.05), there was no significantly increasing in mean level of Placental Growth factor in smoker than non-smoker normal pregnant women group (p value >0.05). Conclusion: Increasing gene expression of Placental Growth factor in trophoblast villi by smoking in early pregnancy lead to increase synthesis of PlGF in spite of increase oxygen concentration that leads to increase smoker maternal serum level of Placental Growth factor.
Keywords
Threatened abortion; Placental Growth Factor; smoker mothers

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