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Synthesis and Antibacterial Screening of New Schiff Bases Based on N-(4-acetophenyl) Succinimide | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 58, Issue 4, 2018, Pages 1790-1801 | ||
| Authors | ||
| Ahlam Marouf Al-Azzawi; Ali Abd Al-Kareem Raheem | ||
| Abstract | ||
| A series of nine new Schiff bases based on N-(4-acetophenyl)succinimide were synthesized via multistep synthesis. In the first step N-(4-acetophenyl)succinamic acid was prepared via reaction of succinic anhydride with 4-aminoacetophenone. The prepared amic acid was dehydrated in the second step producing N-(4-acetophenyl)succinimide. The prepared succinimide represents a modified methyl ketone bearing succinimde cycle and ready for introducing in condensation reaction thus in the third step the prepared imide was introduced in acid-catalyzed condensation reaction with a variety of primary aromatic amines affording the new target Schiff bases. The results of antibacterial screening of the newly synthesized Schiff bases indicated that they possess high antibacterial activity. | ||
| Keywords | ||
| acetophenyl; schiff bases; Succinamic acids | ||
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