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In Vitro Evaluation of Nanochitosan Derivatives and Streptomycin on RD Cell Line and Leishmania Tropica | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 20, Issue 4, 2017, Pages 77-80 | ||
| Authors | ||
| Ali Shehab Ahmed; Muna Mohammed Khayri; Mohammed M. F. Al-Halbosiy | ||
| Abstract | ||
| The study aimed to evaluate in vitro the efficiency of the nano-encapsulated streptomycin within carboxymethylnanochitosan synthesized by an acid-base method on Rhabdomyosarcoma RD cell line and Leishmania tropica. Results showed that the concentrations 100 and 50 µg/ml of encapsulated streptomycin were more effective than 50 and 100 µg/ml of streptomycin alone and inhibited the growth of RD cells to 56 and 35 vs. 19.45 and 23% respectively after 24 hrs of incubation. Carboxymethylnanochitosan at a concentration of 50 µg/ml has the anticancer ability since it inhibited the growth of RD cells up to 20% in comparison with 19% for streptomycin at the same concentration. The growth inhibition of L. tropica in the presence of streptomycin, carboxymethylnanochitosan and streptomycin encapsulated within carboxymethylnanochitosan at 100 µg/ml for each was 34.4, 36 and 29.5% respectively. Carboxymethylnanochitosan is then considered the most effective inhibitor of L. tropica growth. | ||
| Keywords | ||
| Carboxymethylnanochitosan; Encapsulation; RD cell line; Leishmania tropica; Growth Inhibition | ||
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