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Determination of the Level of some Adipokines in Hypo-and Hyperthyroids Patients in Baghdad City | ||
| Baghdad Science Journal | ||
| Article 1, Volume 14, Issue 4, 2017, Pages 713-716 | ||
| Author | ||
| Suha A. Al-Jowari | ||
| Abstract | ||
| Determination of the level of adipokines (obestatin, vaspin, tumor necrosis factor- and interleukin-6)in hypo-and hyperthyroid patients from Educational Baghdad Hospital in Baghdad City was investigated. Fifty patients with hypothyroidism and Fifty patients with hyperthyroidism were selected. A control group of thirty euthyroid persons was included. Blood was collected by vein puncture and serum was separated and stored at –20C. Adipokines (obestatin, vaspin, tumor necrosis factor- and interleukin-6) were estimated using ELISA method. The findings show a significant (p<0.05) increase in obestatin level in hypothyroid patients, while there is no significant difference in hyperthyroid patientsas compared with the euthyroid subjects. In addition, this study demonstrated a significant (p<0.05) increase in vaspin means in hypothyroid patients compared with euthyroid group. In hyperthyroid patients, there is a significant (p<0.05) decrease in vaspin level in comparison with euthyroid subjects. Furthermore, there is a significant (p<0.05) increase in tumor necrosis factor- level in hypothyroid and hyperthyroid patients as compared with the euthyroid subjects. The results of this study also explain a significant (p<0.05) increase in interleukin-6 level in hyperthyroid patients, while there is non-significant difference in hypothyroid patients compared with the euthyroid subjects. It is concluded from this study that the levels of interleukin-6 and tumor necrosis factor- increased in hyperthyroidism and decreased in hypothyroidism. Obestatin and vaspin were increased significantly in hypothyroid patients. | ||
| Keywords | ||
| Obestatin; vaspin; tumor necrosis factor; Interleukin; hyperthyroid | ||
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