H. Nasser, N., H. Hammud, N., A. Hasan, S., Hamid Abdalsadh, A., kareem Hussein, A. (2017). Design and Synthesis of new Naproxen Analogues as Potential Antiinflammatory Agents. , 17(1), 73-81.
Noor H. Nasser; Nethal H. Hammud; Samer A. Hasan; Abbas Hamid Abdalsadh; Ahmed kareem Hussein. "Design and Synthesis of new Naproxen Analogues as Potential Antiinflammatory Agents". , 17, 1, 2017, 73-81.
H. Nasser, N., H. Hammud, N., A. Hasan, S., Hamid Abdalsadh, A., kareem Hussein, A. (2017). 'Design and Synthesis of new Naproxen Analogues as Potential Antiinflammatory Agents', , 17(1), pp. 73-81.
H. Nasser, N., H. Hammud, N., A. Hasan, S., Hamid Abdalsadh, A., kareem Hussein, A. Design and Synthesis of new Naproxen Analogues as Potential Antiinflammatory Agents. , 2017; 17(1): 73-81.

Design and Synthesis of new Naproxen Analogues as Potential Antiinflammatory Agents

Al-Mustansiriyah Journal for Pharmaceutical Sciences
Article 1, Volume 17, Issue 1, 2017, Pages 73-81
Authors
Noor H. Nasser; Nethal H. Hammud; Samer A. Hasan; Abbas Hamid Abdalsadh; Ahmed kareem Hussein
Abstract
4-aminobenzenesulfonamide derivatives were linked to α-carbon of naproxen a non-selective non-steroidal anti-inflammatory drug (NSAID) to increase its size, so; increase its selectivity toward COX-2 enzyme, rather than COX-1 enzyme, that lead to reduce gastrointestinal side effects of this drug.
The chemical structures of the synthesized compounds and their intermediates were confirmed and characterized using elemental microanalysis (CHN), FTIR, and other physicochemical properties like melting points, Rf values.
Keywords
amine derivatives; anti; inflammatory Agents; derivatives of naproxen
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