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The proteomic expression of Neogene nuclear apoptosis-inducing factor 1(NAIF1) in Leukaemia cell lines | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 17, Issue 1, 2017, Pages 82-87 | ||
| Author | ||
| Ahmed H. Qasim | ||
| Abstract | ||
| The process of molecular domestication which had been occured in some DNA transposons (2nd class of transposable elements) led to the formation of novel genes, which are called “Neogenes”. These neogenes may play an important role in the human genetic instability, hu-man diseases and cancer. One of these Neogene is nuclear apoptosis-inducing factor 1(NAIF1) which inducing apoptosis in various human cancers. The aim of this work is to study the expression of NAIF1 Neogene in leukaemia cell lines. The protein expression of NAIF1gene has been studied by western blot method in seven leu-kaemia cell lines (HL60, NB4, KG1, KG1a, ML2, THP1 and U937) and in a healthy tissue of blood as a control. The result of this study showed that the protein expression of NAIF1 in leukaemia cell lines were found in variable degree of expression, which was highly expressed in healthy blood tis-sue. From the results of this work, it can be concluded that NAIF1 protein may have a role in inhi-bition of proliferation, migration and invasion of leukaemia by inducing apoptosis, which need further research and confirmation. | ||
| Keywords | ||
| DNA transposons; domestication; Neogene; NAIF; microsatellite instable; microsatellite sta; ble; and leukaemia cell lines | ||
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