Visfatin Level and its Relation with Obesity and Insulin Resistance In Iraqi Type 2 Diabetes Mellitus Patients

Kareem Y. AL-Samarraie, Abdul; Thair Tahir ALKhalidy, Noor; M.Ali Rajeb, Tariq

	Visfatin Level and its Relation with Obesity and Insulin Resistance In Iraqi Type 2 Diabetes Mellitus Patients
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 30, Issue 1, 2017, Pages 25-30
Authors
Abdul Kareem Y. AL-Samarraie; Noor Thair Tahir ALKhalidy; Tariq M.Ali Rajeb
Abstract
Background: Obesity is highly associated with insulin resistance and increased risk of type 2 diabetes and cardiovascular disease. Visfatin is adipocytokines that is highly expressed in visceral fat. Its expression in visceral fat is hyperglycemia in insulin deficient diabetes. Objective: To study the visfatin level in type 2 diabetes mellitus patients and its relation with obesity and insulin resistance. Patients and methods: This study was done in national diabetes center(NDC),AL -Mustansria University and AL –Yarmok Hospital Teaching ; on a total (120) individuals age range from (33-60) years. ( 80) patient type 2 diabetes nephropathy, (40) healthy controls . The enrolled patients were divided to three groups according to BMI ,data collection about age, sex ,WHR, BMI and blood samples to estimate serum visfatin levels, fasting plasma glucose(FPG), glycated hemoglobin(HbA1c), lipid profile (TC,TG,HDL-C,and LDL-C), fasting C-Peptide ,and fasting insulin level Furthermore insulin resistance parameters calculated from Homeostasis Model Assessment 2- insulin Resistance were calculated using HOMA2-Calculator software downloaded freely . Results: The mean FPG,HbA1c, C-Peptide level, fasting insulin level ,HOMA2IR and visfatin level show statistically significantly increased in diabetic patients when compared with control subjects. Serum visfatin level was significantly increased with BMI increased groups. Visfatin level was increased in HOMA2-IR =>3 when compared with HOMA2-IR <3 in diabetic patients. Visfatin level show significant positive coorelation with BMI, WHR,FPG, HbA1c, fasting insulin level , HOMA2-IR , TC,TG,and LDL-C in diabetic patients when compared with control subjects ,and negative correlation between serum visfatin level and HDL-C in diabetic patients when compared with control subjects . Conclusion: Obesity and Insulin resistance play an important role in the pathophysiology of type 2 diabetes mellitus. Elevated visfatin level in diabetic patients with obesity features of insulin resistance are believed to result in distance clinical characteristics and complications such as atherosclerosis.
Keywords
Obesity; Insulin resistance; visfatin

Statistics Article View: 106 PDF Download: 6